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publications

Mutation of the BRCA1 SQ-cluster results in aberrant mitosis, reduced homologous recombination, and a compensatory increase in non-homologous end joining

Published in Oncotarget, 2015

Characterization of BRCA1 SQ-cluster role in DNA repair pathway selection.

Recommended citation: Beckta JM, Dever SM, Gnawali N, Khalil A, Sule A, Golding SE, Rosenberg E, Wheelhouse RT, Yao Z, Povirk LF, Valerie K. (2015). "Mutation of the BRCA1 SQ-cluster results in aberrant mitosis, reduced homologous recombination, and a compensatory increase in non-homologous end joining." Oncotarget. 6(29):27674.
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Radiosensitizing Glioma by Targeting ATM with Small Molecule Inhibitors

Published in Strategies to Enhance the Therapeutic Ratio of Radiation as a Cancer Treatment, 2016

Book chapter on ATM inhibition strategies for glioma radiosensitization.

Recommended citation: Sule A, Valerie K. (2016). "Radiosensitizing Glioma by Targeting ATM with Small Molecule Inhibitors." In: Strategies to Enhance the Therapeutic Ratio of Radiation as a Cancer Treatment.

Published in , 1900

The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models

Published in Science Advances, 2018

Preclinical development of brain-penetrant ATM inhibitor for glioblastoma treatment.

Recommended citation: Durant ST, Zheng L, Wang Y, Chen K, Zhang L, Zhang T, Yang Z, Riches L, Trinidad AG, Fok JHL, Hunt T, Pike KG, Wilson J, Smith A, Colclough N, Reddy VP, Sykes A, Janefeldt A, Johnström P, Varnäs K, Takano A, Ling S, Orme J, Stott J, Roberts C, Barrett I, Jones G, Roudier M, Pierce A, Allen J, Kahn J, Sule A, et al. (2018). "The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models." Science Advances. 4(6):eaat1719.
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PEAMOtecan, a novel chronotherapeutic polymeric drug for brain cancer

Published in Journal of Controlled Release, 2020

Development of novel chronotherapeutic drug delivery system for brain cancer.

Recommended citation: Allen J, Wang J, Zolotarskaya OY, Sule A, Mohammad S, Arslan S, Godin B, Nan A, Valerie K. (2020). "PEAMOtecan, a novel chronotherapeutic polymeric drug for brain cancer." Journal of Controlled Release. 321:36-48.
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Persistent STAG2 mutation despite multimodal therapy in recurrent pediatric glioblastoma

Published in NPJ Genomic Medicine, 2020

Study of genetic mutations in recurrent pediatric glioblastoma.

Recommended citation: Hong CS, Vasquez JC, Kundishora AJ, Elsamadicy AA, Beckta JM, Sule A, Despotí M, Kahle KT, Bindra RS. (2020). "Persistent STAG2 mutation despite multimodal therapy in recurrent pediatric glioblastoma." NPJ Genomic Medicine. 5(1):23.
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Published in , 1900

Targeting Krebs-cycle-deficient renal cell carcinoma with Poly ADP-ribose polymerase inhibitors and low-dose alkylating chemotherapy

Published in Oncotarget, 2022

Novel therapeutic approach for Krebs-cycle-deficient renal cell carcinoma.

Recommended citation: Ueno D, Vasquez JC, Sule A, Liang J, van Doorn J, Sundaram R, Bindra RS. (2022). "Targeting Krebs-cycle-deficient renal cell carcinoma with Poly ADP-ribose polymerase inhibitors and low-dose alkylating chemotherapy." Oncotarget. 13:1054.
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Mismatch repair proteins play a role in ATR activation upon temozolomide treatment in MGMT-methylated glioblastoma

Published in Scientific Reports, 2022

Elucidation of mismatch repair protein role in ATR activation in glioblastoma.

Recommended citation: Ganesa S, Sule A, Sundaram RK, Bindra RS. (2022). "Mismatch repair proteins play a role in ATR activation upon temozolomide treatment in MGMT-methylated glioblastoma." Scientific Reports. 12(1):5827.
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ATM phosphorylates PP2A subunit A resulting in nuclear export and spatiotemporal regulation of the DNA damage response

Published in Cellular and Molecular Life Sciences, 2022

Identification and characterization of novel ATM-PP2A-Aα signaling axis in DNA damage response.

Recommended citation: Sule A, Golding SE, Ahmad SF, Watson J, Ahmed MH, Kellogg GE, Bernas T, Koebley S, Reed JC, Povirk LF, Valerie K. (2022). "ATM phosphorylates PP2A subunit A resulting in nuclear export and spatiotemporal regulation of the DNA damage response." Cellular and Molecular Life Sciences. 79(12):603.
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The human and non-human primate developmental GTEx projects

Published in Nature, 2025

Large-scale developmental genomics study profiling cellular heterogeneity across human and non-human primate development.

Recommended citation: Coorens THH, Guillaumet-Adkins A, Kovner R, Linn RL, Roberts VHJ, ..., Sule A, et al. (2025). "The human and non-human primate developmental GTEx projects." Nature. 637(8046):557-564.
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Nuclei isolation from fresh frozen tissues for 10X Single Cell Multiome ATAC+ Gene Expression Sequencing

Published in protocols.io, 2025

Standardized protocol for nuclei isolation for single-cell multiome sequencing.

Recommended citation: Guillaumet-Adkins A, Sule A. (2025). "Nuclei isolation from fresh frozen tissues for 10X Single Cell Multiome ATAC+ Gene Expression Sequencing and other technologies." protocols.io.
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teaching

Teaching experience 1

Undergraduate course, University 1, Department, 2014

This is a description of a teaching experience. You can use markdown like any other post.

Teaching experience 2

Workshop, University 1, Department, 2015